University of Southern California


Congratulations to the following authors for their recent publications featuring data generated in the USC Flow Cytometry Core Facility:


  • Zhang H, Boddupally K, Kandyba E, Kobielak K., Chen Y, Zu S, Krishnan R, Sinha U, Kobielak A. Defining the localization and molecular characteristic of minor salivary gland label-retaining cells. Stem Cells. 2014 Aug;32(8):2267­–77.
  • Lua I, James D, Wang J, Wang KS, Asahina K. Mesodermal mesenchymal cells give rise to myofibroblasts, but not epithelial cells, in mouse liver injury. Hepatology. 2014 Jul;60(1):311­–22.
  •  Tolani B, Gopalakrishnan R, Punk V, Matta H, Chaudhary PM. Targeting Myc in KSHV-associated primary effusion lymphoma with BET bromodomain inhibitors. Oncogene. 2014 May 29;33(22):2928–37.
  • Geary LA, Nash KA, Adisetiyo H, Liang M, Liao CP, Jeong JH, Zandi E, Roy-Burman P. CAF-secreted annexin A1 induces prostate cancer cells to gain stem cell-like features. Mol Cancer Res. 2014 Apr;12(4):607­–21.
  • Kandyba E, Kobielak K. Wnt7b is an important intrinsic regulator of hair follicle stem cells and hair follicle cycling. Stem Cells. 2014 April;32(4):886–901.
  • Kandyba E, Hazen VM, Kobielak A, Butler SJ, Kobielak K. Smad1 and 5 but not Smad8 establish stem cell quiescence which is critical to transform the premature hair follicle during morphogenesis toward the postnatal state. Stem Cells. 2014 Feb;32(2):534­–47.


  • Luo B, Tseng CC, Adams G, Lee AS. Deficiency of GRP94 in the hematopoietic system alters proliferation regulators in hematopoietic stem cells. Stem Cell Dev. 2013 Dec 1;22(23):3062–73.
  • Leung Y, Kandyba E, Chen YB, Ruffins S, Kobielak K. Label retaining cells (LRCs) with myoepithelial characteristic from the proximal acinar region define stem cells in the sweat gland. Plos One. 2013 Sep 18;8(9):e74174. [Free Article]
  • Gopalakrishnan R, Matta H, Chaudhary PM. A purine scaffold HSP90 inhibitor BIIB021 has selective activity against KSHV-associated primary effusion lymphoma and blocks vFLIP K13-induced NF-κB. Clin Cancer Res. 2013 Sep 15;19(18):5016­–26.
  • Graham C, Matta H, Yang Y, Yi H, Suo Y, Tolani B, Chaudhary PM. Kaposi’s sarcoma-associated herpesvirus oncoprotein K13 protects against B cell receptor-induced growth arrest and apoptosis through NF-κB activation. J Virol. 2013 Feb;87(4):2242­–52. [Free Article]
  • Kandyba E, Leung Y, Bu Y, Widelitz R, Chuong CM, Kobielak K. Competitive balance of intrabulge BMP/Wnt signaling reveals a robust gene network ruling stem cell homeostasis and cyclic activation. PNAS. 2013 Jan 22;110(4):1351­–6. [Free Article]


  • Lechner MG, Megiel C, Church CH, Russell SM, Sevell RB, Jang JK, Brody GS, Epstein AL. Survival signals and targets for therapy in breast implant-associated ALK-anaplastic large cell lymphoma. Clin Cancer Res. 2012 Sep 1;18(17):4549—59. [Free Article]
  • Murphy KA, Lechner MG, Popescu FE, Bedi J, Decker SA, Hu P, Swier L, Salazar AM, Olin MR, Epstein AL, Ohlfest JR. An in vivo immunotherapy screen identifies Fc-mOX40L as a potent drug capable of causing regression of established murine gliomas. Clin Cancer Res. 2012 Sep 1;18(17):4657—68.
  • Wey S, Luo B, Lee A. Acute inducible ablation of GRP78 reveals its role in hematopoietic stem cell survival, lymphogenesis, and regulation of stress signaling. PLos One. 2012 Jun 18;2012; 7(16). [Free Article]
  • Das A, Crump JG. Bmps and Id2a act upstream of Twist1 to restrict ectomesenchyme potential of the cranial neural crest. PLoS Genetics. 2012 May:8(5): e1002710. [Free Article]
  • Zhao Z, Oh S, Li D, Ni D, Pirooz SD, Lee JH, Yang S, Lee JY, Ghozalli I, Costanzo V, Stark JM, Liang C. A dual role for UVRAG in maintaining chromosomal stability independent of autophagy. Dev Cell. 2012 May 15;22(5):1001–16. [Free Article]
  • Lee NS, Rohan JG, Zitting M, Kamath S, Weitz A, Sipos A, Salvaterra PM, Hasegawa K, Pera M, Chow RH. A Novel Dual-Color Reporter for Identifying Insulin-Producing Beta- Cells and Classifying Heterogeneity of Insulinoma Cell Lines. PLoS ONE. 2012 Apr 18. 7(4):1—11. [Free Article]
  • Luo B, Lee AS. The critical roles of endoplasmic reticulum chaperones and unfolded protein response in tumorigenesis and anticancer therapies. Oncogene. 2012 Apr 16;32: 805–818.
  • Wey S, Luo B, Tseng CC, Ni M, Zhou H, Fu Y, Bhojwani D, Carroll WL, Lee AS. Inducible knockout of GRP78/BiP in the hematopoietic system suppresses Pten-null leukemogenesis and AKT oncogenic signaling. Blood. 2012 Jan 19;119(3):817—25.


  • Mumenthaler SM, Foo J, Leder K, Choi NC, Agus DB, Pao W, Mallick P, Michor F. Evolutionary modeling of combination treatment strategies to overcome resistance to tyrosine kinase inhibitors in non-small cell lung cancer. Mol Pharm. 2011 Dec 5;8(6): 2069—79. [Free Article]
  • Chen F, Chen GK, Millikan RC, John EM, Ambrosone CB, Bernstein L, Zheng W, Hu JJ, Ziegler RG, Deming SL, Bandera EV, Nyante S, Palmer JR, Rebbeck TR, Ingles SA, Press MF, Rodriguez-Gil JL, Chanock SJ, Le Marchand L, Kolonel LN, Henderson BE, Stram DO, Haiman CA. Fine-mapping of breast cancer susceptibility loci characterizes genetic risk in African Americans. Hum Mol Genet. 2011 Nov 15;20(22):4491—503.
  • Lechner MG, Russell SM, Bass RS, Epstein AL. Chemokines, costimulatory molecules and fusion proteins for the immunotherapy of solid tumors. Immunotherapy. 2011 Nov;3(11):1317—40. [Free Article]
  • Haiman CA, Chen GK, Vachon CM, Canzian F, Dunning A, Millikan RC, Wang X, Ademuyiwa F, Ahmed S, Ambrosone CB, Baglietto L, Balleine R, Bandera EV, Beckmann MW, Berg CD, Bernstein L, Blomqvist C, Blot WJ, Brauch H, Buring JE, Carey LA, Carpenter JE, Chang-Claude J, Chanock SJ, Chasman DI, Clarke CL, Cox A, Cross SS, Deming SL, Diasio RB, Dimopoulos AM, Driver WR, Dünnebier T, Durcan L, Eccles D, Edlund CK, Ekici AB, Fasching PA, Feigelson HS, Flesch-Janys D, Fostira F, Försti A, Fountzilas G, Gerty SM; Gene Environment Interaction and Breast Cancer in Germany (GENICA) Consortium, Giles GG, Godwin AK, Goodfellow P, Graham N, Greco D, Hamann U, Hankinson SE, Hartmann A, Hein R, Heinz J, Holbrook A, Hoover RN, Hu JJ, Hunter DJ, Ingles SA, Irwanto A, Ivanovich J, John EM, Johnson N, Jukkola-Vuorinen A, Kaaks R, Ko YD, Kolonel LN, Konstantopoulou I, Kosma VM, Kulkarni S, Lambrechts D, Lee AM, Marchand LL, Lesnick T, Liu J, Lindstrom S, Mannermaa A, Margolin S, Martin NG, Miron P, Montgomery GW, Nevanlinna H, Nickels S, Nyante S, Olswold C, Palmer J, Pathak H, Pectasides D, Perou CM, Peto J, Pharoah PD, Pooler LC, Press MF, Pylkäs K, Rebbeck TR, Rodriguez-Gil JL, Rosenberg L, Ross E, Rüdiger T, Silva Idos S, Sawyer E, Schmidt MK, Schulz-Wendtland R, Schumacher F, Severi G, Sheng X, Signorello LB, Sinn HP, Stevens KN, Southey MC, Tapper WJ, Tomlinson I, Hogervorst FB, Wauters E, Weaver J, Wildiers H, Winqvist R, Van Den Berg D, Wan P, Xia LY, Yannoukakos D, Zheng W, Ziegler RG, Siddiq A, Slager SL, Stram DO, Easton D, Kraft P, Henderson BE, Couch FJ. A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor-negative breast cancer. Nat Genet. 2011 Oct 30;43(12):1210—4. [Free Article]
  • Russell SM, Lechner MG, Gong L, Megiel C, Liebertz DJ, Masood R, Correa AJ, Han J, Puri RK, Sinha UK, Epstein AL. USC-HN2, a new model cell line for recurrent oral cavity squamous cell carcinoma with immunosuppressive characteristics. Oral Oncol. 2011 Sep;47(9):810—7. [Free Article]
  • Park E, Gang EJ, Hsieh YT, Schaefer P, Chae S, Klemm L, Huantes S, Loh M, Conway EM, Kang ES, Hoe Koo H, Hofmann WK, Heisterkamp N, Pelus L, Keerthivasan G, Crispino J, Muschen M, Kahn M, Kim YM. Targeting survivin overcomes drug resistance in acute lymphoblastic leukemia. Blood. 2011 Aug 25; 118(8):2191-9. [Free Article]
  • Rao P, Pham HT, Kulkarni A, Yang Y, Liu X, Knipe DM, Cresswell P, Yuan W. Herpes simplex virus 1 glycoprotein B and US3 collaborate to inhibit CD1d antigen presentation and NKT cell function. J Virol. 2011 Aug;85(16):8093—104. [Free Article]
  • Lechner MG, Megiel C, Russell SM, Bingham B, Arger N, Woo T, Epstein AL. Functional characterization of human Cd33+ and Cd11b+ myeloid-derived suppressor cell subsets induced from peripheral blood mononuclear cells co-cultured with a diverse set of human tumor cell lines. J Transl Med. 2011 Jun 9;9:90. [Free Article]
  • Luo B, Lam BS, Lee SH, Wey S, Zhou H, Wang M, Chen SY, Adams GB, Lee AS. The endoplasmic reticulum chaperone protein GRP94 is required for maintaining hematopoietic stem cell interactions with the adult bone marrow niche. PLoS One. 2011 May 24;6(5):e20364. [Free Article]
  • He K, Xu T, Goldkorn A. Cancer Cells Cyclically Lose and Regain a Drug-Resistant Highly-Tumorigenic Phenotype in Culture and in Tumor Xenografts. Mol Cancer Ther. 2011 Jun;10(6):938—48. [Free Article]
  • Lei Y, Lee CL, Joo KI, Zarzar J, Liu Y, Dai B, Fox V, Wang P. Gene editing of human embryonic stem cells via an engineered baculoviral vector carrying zinc-finger nucleases. Mol Ther. 2011 May;19(5):942—50. [Free Article]
  • Lechner MG, Lade S, Liebertz DJ, Prince HM, Brody GS, Webster HR, Epstein AL. Breast implant-associated, ALK-negative, T-cell, anaplastic, large-cell lymphoma: establishment and characterization of a model cell line (TLBR-1) for this newly emerging clinical entity. Cancer. 2011 Apr 1;117(7):1478—89. [Free Article]
  • Lechner MG, Epstein AL. A new mechanism for blocking myeloid-derived suppressor cells by CpG. Clin Cancer Res. 2011 Apr 1;17(7):1645—8. [Free Article]
  • Lam BS, Cunningham C, Adams GB. Pharmacologic modulation of the calcium-sensing receptor enhances hematopoietic stem cell lodgment in the adult bone marrow. Blood. 2011 Jan 27;117(4):1167—75. [Free Article]


  • Machida K, McNamara G, Cheng KT, Huang J, Wang CH, Comai L, Ou JH, Lai MM. Hepatitis C virus inhibits DNA damage repair through reactive oxygen and nitrogen species and by interfering with the ATM NBS1/Mre11/Rad50 DNA repair pathway in monocytes and heptocytes. J Immunol. 2010 Dec 1;185(11):6985-98. [Free Article]
  • Lau HD, Yaegashi J, Zaro BW, Pratt MR. Precise Control of Protein Concentration in Living Cells. Angewandte Chemie International Edition. 2010 Nov 2;49(45): 8458–8461. [Free Article]
  • Xu T, He K, Wang L, Goldkorn A. Prostate Tumor Cells with Cancer Progenitor Properties Have High Telomerase Activity and Are Rapidly Killed by Telomerase Interference. Prostate. 2010 Sep 15;71(13):1390—400. [Free Article]
  • Lechner MG, Liebertz DJ, Epstein AL. Characterization of cytokine-induced myeloid-derived suppressor cells from normal human peripheral blood mononuclear cells. J Immunol. 2010 Aug 15;185(4):2273-84. [Free Article]
  • Holt N, Wang J, Kim K, Friedman G, Wang X, Taupin V, Crooks GM, Kohn DB, Gregory PD, Holmes MC, Cannon PM. Zinc finger nuclease-mediated CCR5 knockout hematopoietic stem cell transplantation controls HIV-1 in vivoNat Biotechnol. 2010 Aug;28(8):839—47. [Free Article]
  • Machida K, Tsukamoto H, Liu JC, Han YP, Covindarajan S, Lai MM, Akira S, Ou JH. c-Jun mediates hepatitis C virus hepatocarcinogenesis through signal transducer and activator of transcription 3 and nitric oxide-dependent impairment of oxidative DNA repair. Heptaology. 2010 Aug;52(2):480—92. [Full Article]
  • Lopez LA, Yang SJ, Hauser H, Exline CM, Haworth KG, Oldenburg J, Cannon PM. Ebola virus glycoprotein counteracts BST-2/Tetherin restriction in a sequence-independent manner that does not require tetherin surface removal. J Virol. 2010 Jul;84(14):7243—55. [Free Article]
  • Zhang Y, Liu R, Ni M, Gill P, Lee AS. Cell surface relocalization of the endoplasmic reticulum chaperone and unfolded protein response regulator GRP78/BiP. J Biol Chem. 2010 May 14. 285:15065—15075. [Free Article]
  • Zhang P, Andrianakos R, Yang Y, Liu C, Lu W. Kruppel-like factor 4 (Klf4) prevents embryonic stem (ES) cell differentiation by regulating Nanog gene expression. J Biol Chem. 2010 Mar 19; 285(12): 9180—9. [Full Article]
  • Liebertz DJ, Lechner MG, Masood R, Sinha UK, Han J, Puri RK, Correa AJ, Epstein AL. Establishment and characterization of a novel head and neck squamous cell carcinoma cell line USC-HN1. Head Neck Oncol. 2010 Feb 22;2:5. [Free Article]
  • Xu T, Xu Y, Liao CP, Lau R and Goldkorn A. Reprogramming Murine Telomerase Rapidly Inhibits the Growth of Mouse Cancer Cells In Vitro and In Vivo. Molecular Cancer Therapeutics. 2010 Feb 2. 9(2):438—449. [Free Article]
  • Zhang P, Andrianakos R, Yang Y, Liu C and Lu W. Kruppel-like factor 4 (Flf4) prevents embryonic stem (ES) cell differentiation by regulating Nanog gene expression. J Biol Chem. 2010 Jan 13. 285(12)L9180—9. [Free Article]


  • Hough SR, Laslett AL, Grimmond SB, Kolle G, Pera MF. A Continuum of Cell States Spans Pluripotency and Lineage Commitment in Human Embryonic Stem Cells. PLoS ONE. 2009 Nov 5;4(11):e7708. [Free Article]
  • Li R, Beebe T, Cui J, Mahsa R, Ai L, Wand P, Gunderson M, Takabe W, Hsiai TK. Pulsatile Shear Stress Increased Mitochondrial Membrane Potential: Implication of Mn-SOD. Biochem Biophys Res Commun. 2009 October 16; 388(2):406–412. [Free Article]
  • Wei Z, Yang Y, Zhang P, Andrianakos R, Hasegawa K, Lyu J, Chen X, Bai G, Liu C, Pera M, Lu W. Klf Directly Interacts with Oct4 and Sox2 to Promote Reprogramming. Stem Cells. 2009 Oct 8. 27(12):2969—78. [Free Article]